The Osteoarthritis Research Society International's World Congress on Osteoarthritis concluded on April 21, with a clear focus on finding new ways to recognize the disease early and identify and slow progression.
Conferences page on Musculoskeletal Network features reports on the latest in osteoarthritis research, including:
Synovitis is present in 90% of painful knees, and emerging data is showing that this inflammation is "not just a bystander" in osteoarthritis-induced damage. Research is revealing the roles of macrophages and T-cells, and signposts toward new drug targets. More »
No speaker at the OARSI meeting turned up with the Holy Grail -- a new disease modifying osteoarthritis drug (DMOAD). Some promising alternatives are not available to US patients; others are in very preliminary testing. More »
Patients with knee osteoarthritis should have mild exercise every day to reduce inflammation, should walk with shorter steps to reduce knee loading, and should strengthen their upper leg muscles, to judge from new research. But studies have yet to say how much exercise is best, how often, and at... More »
OARSI 2013: More support for the supplement chondroitin sulfate (CS) in osteoarthritis: In a large observational study from Spain, six months' use of CS significantly reduced the likelihood of having total knee replacement. Observers noted the well-known issues in applying this knowledge in the US. More »
(AUDIO) Intensive analysis of protein pathways inside joints is showing strong activity among messengers involved in wound healing. In this podcast, learn about the new research that backs the vision of arthritis as a chronic wound, and the implications for management. More »
Viral causes are implicated in potentially deadly A-DRESS SYNDROME (dermatitis, hepatitis, interstitial nephritis, and eosinophilia) among allopurinol users. Skin biopsy and a wide panel of viral titers are well advised. . ..
Latent Tuberculosis Infection in RA: The Disease and the Diagnosis
Although tuberculosis is common in RA even in the absence of treatment, false-negative tuberculin skin test results are frequent because of either immunosuppressive treatment or a natural waning of immunity. . ..
The quads and hamstrings of OA patients who later have knee replacement seem to be firing continuously, according to new biomechanics research. Training with the Alexander technique may offer relief. . ..
Recognizing and Managing Posterior Cruciate Ligament Injuries
Gradually increasing mild pain in the back of the knee, stiffness, and pain with squatting or kneeling may be the only signs of PCL injury, arising long past the acute period after a seemingly trivial inciting event. . ..
Over two million anterior cruciate ligament (ACL) injuries occur worldwide annually, and the greater prevalence for ACL injury in young female athletes is one of the major problems in sports medicine. Optimal treatment of ACL injury requires individualised management. Patient selection is of utmost importance, and so is respect for the patient's functional demands and interests. All patients with an ACL tear may not need surgery, however athletes and persons with an active lifestyle with high knee fun
Purpose: The purpose of this study was to assess the degree of osteoarthritis, degree of laxity, and quality-of-life (QOL) scores in primary and revision anterior cruciate ligament (ACL) reconstruction.Methods: This was a cross-sectional study; 25 patients who had undergone revision ACL reconstruction with allografts were identified and compared with 27randomly selected primary ACL reconstruction patients operated on in the same hospital in the same period with the same technique. The main outcome mea
Although it is generally accepted that osteoarthritis is a degenerative condition of the cartilage, other tissues such as synovium in which immunological and inflammatory reactions occur contribute to the development of joint pathology. This sheds new light on the potential mechanism of action of mesenchymal stem cell therapy in osteoarthritis. Rather than tissue repair due to local transformation of injected mesenchymal stem cells to chondrocytes and filling defects in cartilage, such treatment might sup