(AUDIO) Dr. Mark Shlomchik has won the first $200,000 Insight Prize for research that led toward new lupus drugs such as belimumab. In a brief recorded interview, hear how the award may help him find an explanation for the links between infection and lupus.

A new era in hepatitis C treatment began in May 2011, with approval of telaprevir and boceprevir. They are effective only for some patients, but new and better options are well on their way to the clinic.

Does the lupus patient have comorbid age-related osteoarthritis? Is it iliopsoas bursitis or trochanteric pain syndrome? Eight images with reflections on differential diagnosis of hip pain.

Like so many inflammatory conditions, complex regional pain syndrome (yes, there's growing evidence it's inflammatory) demands early treatment. Yet it is devilishly difficult to recognize its initial stages. Here are the signs, and an algorithm for management.

New this week in the major non-specialty journals: Report of an increased risk for arthropathy in statin users, and case reports on polyarteritis nodosa and a rare mimic of scleroderma.

Data from a national registry of ankylosing spondylitis reveal that patients not finding relief from one THF inhibitor usually benefit from trying a different one.

New in the non-specialty journals: Major reviews on pain relief (NSAIDs and opioids) and further reflections on judging some procedures unnecessary and overused.

A review of five clinical trials shows that a new subcutaneous formulation of abatacept (Orencia) is as safe and effective short-term in rheumatoid arthritis (RA) as intravenous abatacept, maintaining improvements in clinical and functional efficacy over time.

A phase I pharmacokinetic clinical trial shows that escalating doses of oral treprostinil diethanolamine temporarily improve cutaneous perfusion and temperature in scleroderma patients with peripheral vascular disease and digital ulcers.

New in the nonspecialty journals: Capitalizing on what controls citrullination. Gene studies at a dead end for autoimmunity? Still more cautions about steroid injections, and more.

Women with persistent antiphospholipid antibodies (aPLs) apparently have pregnancy outcomes similar to those of women under treatment for antiphospholipid syndrome (APS) and even comparable to unmatched controls.

New in the nonspecialty journals: A new option for patients with autoimmune disease and HCV infection. The value of combined therapy for osteoporosis. Prognosis predictors for chronic pain, a new opioid adverse effect, and more ...

They may be supported by guidelines and commonly used in practice, but joint injections with glucocorticoids for acute gout are not backed by any randomized controlled clinical trials, according to a new Cochrane report. However, the report backs away from saying they should not be used.

An 82-year-old man presented with longstanding bilateral hip pain but no history of trauma. (Why might you have expected him to arrive requiring care many years earlier?) The diagnosis in this image-rich case study is discussed by Dr. Bogner, a radiologist at Hospital for Special Surgery.

A 39-year-old woman, in her eighth week of pregnancy, experienced aching pain that worsened with activity. Weakness and fatigue set in three days later in her thigh and proximal arm muscle. Then a mildly pruritic rash developed across the forehead, nose, and forearms.

An obese woman in her thirties with a history of fibromyalgia syndrome, depression, polycystic ovarian syndrome, and diabetes presents with midline back pain that has gradually worsened over the past week.

A 56-year-old woman presents with a history of intermittent shoulder pain for the past six months. Early signs point to bursitis, but the plot thickens: She also has sarcoidosis and lymphoma. How would you proceed?

A 44-year-old nonsmoking immigrant from Taiwan sought help from a dermatologist for this longstanding skin eruption, lately complicated by weight loss and fatigue.