A 61-year-old man with arthritis and an 80-pack-year smoking history presented with fever, dyspnea, and productive cough of a week’s duration that did not respond to outpatient treatment with levofloxacin. More »
Platelet-rich plasma (PRP) is derived from autologous blood and prepared so that the platelet concentration is above baseline value. Platelets contain growth factors necessary for tissue healing. More »
Drug-induced rash with eosinophilia and systemic symptoms (DRESS) syndrome may be triggered by numerous chemically unrelated medications. Allopurinol-induced DRESS (A-DRESS) syndrome carries the highest mortality risk. More »
The therapeutic options for psoriatic arthritis (PsA) have expanded rapidly and improved patients’ pain, function, and quality of life. However, many patients do not respond to the current disease-modifying medications or cannot take them. Oral methotrexate is the leading disease-modifying... More »
The United States Bone and Joint Decade (USBJD), a musculoskeletal disease awareness campaign entering its 10th year, has received a mandate to continue its work beyond 2011. More »
Clinical guidelines for the management of juvenile idiopathic arthritis (JIA) recently released by the American College of Rheumatology (ACR) focus on the initiation and safety monitoring of treatment with multiple medications. More »
Background: Diagnosis and identification of the etiological agent of septic arthritis (SA) in children is an important issue, as early treatment based on accurate diagnosis of joint infections can prevent potentially disabling complicat
Background: Pasteurella spp. are important bacterial pathogens in both animals and humans. Most reported Pasteurella infections in humans involve skin and soft tissues, often after an animal bite, scratch, or lick to an open wound. Infectio
In humans, different B-cell subpopulations can be distinguished in peripheral blood and other tissues on the basis of differential expression of various surface markers. These different subsets correspond to different stages of maturation, activation and differentiation. B-cell depletion therapy based on rituximab, an anti-CD20 mAb, is widely used in the treatment of various malignant and autoimmune diseases. Rituximab induces a very significant depletion of B-cell subpopulations in the peripheral blood u
Over the past few decades small animal models mainly involving rodents and rabbits have been developed whereby needle puncture, stab incision or enzymatic approaches have been validated to create the degenerative disc. Although important these models continue to be plagued by biological attributes that limit applicability to the human condition. However the fascinating story of the naturally occurring subspecies of canine, the non-chondrodystrophic (NCD) and chondrodystrophic (CD) canine provides us wit
Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the pathology of Rheumatoid Arthritis (RA), particularly as vulnerable personality types are exposed to chronic stress. Emotions are powerful modulators of stress responses. However, little is known about whether patients with RA process emotions differently to matched controls. In this study we: 1) assessed whether the trait emotional intelligence (trait EI) scores of patients with RA differ from healthy controls at the
Primary Care Can't Thrive Without Nurse Practitioners Courtney H. Lyder, ND, May 17, 2013 With a projected shortfall of primary-care physicians, it's time for alternate solutions to patient care. Nurse practitioners are one logical remedy.
