Rheumatology Network en Copyright 2009, CMPMedica US Mon, 20 May 2013 14:00:01 GMT Mon, 20 May 2013 14:00:01 GMT http://blogs.law.harvard.edu/tech/rss http://www.musculoskeletalnetwork.com/skin-diseases/content/article/1145622/2142974?CID=rss <img width="100" height="80" src="http://www.consultantlive.com/image/image_gallery?img_id=1387374" alt="" border="0" align="left" style="padding-right:5px;" />Is it a form of lupus, myositis, or a drug reaction? Check your knowledge of skin eruptions and the associated rheumatologic conditions in this brief photo essay.<br style="clear:both;"/> Fri, 17 May 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/display/article/1145622/2142812?CID=rss he FDA has approved the tumor necrosis factor (TNF) blocker golimumab (Simponi) for treatment of moderate to severe ulcerative colitis in adults. This is the first non-arthritis indication for the biologic, which is already approved for rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis. Thu, 16 May 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/gout/content/article/1145622/2142734?CID=rss They may be supported by guidelines and commonly used in practice, but joint injections with glucocorticoids for acute gout are not backed by any randomized controlled clinical trials, according to a new Cochrane report. However, the report backs away from saying they should not be used. Wed, 15 May 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/rheumatic-diseases/content/article/1145622/2142468?CID=rss A small, randomized clinical trial from Germany suggests that two weeks of high-dose oral prednisone produces a clinically relevant response in patients with active ankylyosing spondylitis (AS) refractory to NSAIDs. Tue, 14 May 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/rheumatic-diseases/content/article/1145622/2142411?CID=rss New in the non-rheumatology journals, much about pain: A review based on 2012 fibromyalgia guidelines from Canada, a viewpoint on safe use of opioids, the evidence to back spinal pain interventions. Also: fast-track arthroplasty, and more newfound genes. Mon, 13 May 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/juvenile-arthritis/content/article/1145622/2141822?CID=rss The FDA has approved canakinumab (Ilaris) for treatment of active systemic juvenile idiopathic arthritis) in patients aged 2 years and older. The drug is administered monthly by subcutaneous injection. Fri, 10 May 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/rheumatoid-arthritis/content/article/1145622/2141462?CID=rss In a comprehensive review of clinical trials, combination therapies with biologics offered better chances of long-term remission than monotherapy with a DMARD. Wed, 8 May 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/rheumatic-diseases/content/article/1145622/2141440?CID=rss New in the non-rheumatology journals: Adverse effects of TNF-α inhibitors, a comment on meniscectomy vs. physical therapy, and the latest on adolescent scoliosis. Tue, 7 May 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/rheumatoid-arthritis/content/article/1145622/2140798?CID=rss Quest Diagnostics says the biomarker 14-3-3eta in its new test greatly improves sensitivity in detecting early rheumatoid arthritis. But the data is not yet published. Fri, 3 May 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/osteoarthritis/content/article/1145622/2140555?CID=rss New research has examined 3D motion and muscle activity in knee osteoarthritis, and correlated gait with pain. Result: a better description of knees destined for replacement. Thu, 2 May 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/rheumatic-diseases/content/article/1145622/2140536?CID=rss <img width="110" height="75" src="http://imaging.cmpmedica.com/shared/zone5/0809JMMIMDF1.jpg" alt="" border="0" align="left" style="padding-right:5px;" />A 39-year-old woman, in her eighth week of pregnancy, experienced aching pain that worsened with activity. Weakness and fatigue set in three days later in her thigh and proximal arm muscle. Then a mildly pruritic rash developed across the forehead, nose, and forearms.<br style="clear:both;"/> Wed, 1 May 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/osteoarthritis/content/article/1145622/2140524?CID=rss Synovitis is present in 90% of painful knees, and emerging data is showing that this inflammation is "not just a bystander" in osteoarthritis-induced damage. Research is revealing the roles of macrophages and T-cells, and signposts toward new drug targets. Wed, 1 May 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/osteoporosis/content/article/1145622/2140115?CID=rss A small randomized trial from Italy found that while zoledronic acid (Reclast) slows bone loss in osteoporosis, it may also slow bone formation. Perhaps combination therapy is required. Fri, 19 Apr 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/rheumatic-diseases/content/article/1145622/2140021?CID=rss Two major examples of "crowdsourcing" genetic explanations for rheumatic diseases: a competition to explain the genetics of anti-TNF response in rheumatoid arthritis, and 14 newfound genes for juvenile idiopathic arthritis. Mon, 29 Apr 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/lupus/content/article/1145622/2139895?CID=rss A small pilot trial from the Karolinska Institute finds positive results for rituximab in lupus nephritis patients for whom conventional treatments have failed. Fri, 26 Apr 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/rheumatoid-arthritis/content/article/1145622/2139846?CID=rss Pain, function and quality of life scores from 11% of patients with early rheumatoid arthritis rate the condition as “worse than death,” according to French researchers, with extreme pain and discomfort being a key determinant. Fri, 26 Apr 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/osteoarthritis/content/article/1145622/2139640?CID=rss No speaker at the OARSI meeting turned up with the Holy Grail -- a new disease modifying osteoarthritis drug (DMOAD). Some promising alternatives are not available to US patients; others are in very preliminary testing. Thu, 25 Apr 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/osteoarthritis/content/article/1145622/2139542?CID=rss Patients with knee osteoarthritis should have mild exercise every day to reduce inflammation, should walk with shorter steps to reduce knee loading, and should strengthen their upper leg muscles, to judge from new research. But studies have yet to say how much exercise is best, how often, and at what intensity. Wed, 24 Apr 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/osteoarthritis/content/article/1145622/2139321?CID=rss What you want to see in progressive images of knee osteoarthritis is not a particular kind of change, but homeostasis, to judge from two studies presented at the annual meeting of OARSI. Tue, 23 Apr 2013 12:00:00 GMT http://www.musculoskeletalnetwork.com/fibromyalgia/content/article/1145622/2139011?CID=rss <img width="80" height="100" src=http://www.musculoskeletalnetwork.com/image/image_gallery?img_id=2139009&t=1366665617400" alt="" border="0" align="left" style="padding-right:5px;" />A discovery that patients with fibromyalgia showed signs of small fiber impairment not present in depressed patients or controls may point to the first objectively measurable alteration of the peripheral nervous system in this disorder.<br style="clear:both;"/> Mon, 22 Apr 2013 12:00:00 GMT